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Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis

3 Oct 2014

Abstract excerpt

INTRODUCTION: Synovial fibroblasts invade cartilage and bone, leading to joint destruction in rheumatoid arthritis. However, the mechanisms that regulate synovial fibroblast invasion are not well understood. Focal adhesion kinase (FAK) has been implicated in cellular invasion in several cell types, and FAK inhibitors are in clinical trials for cancer treatment. Little is known about the role of FAK in...

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PMID: 25280866
DOI: 10.1186/s13075-014-0464-6

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