Article
Lachnum polysaccharide suppresses S180 sarcoma by boosting anti-tumor immune responses and skewing tumor-associated macrophages toward M1 phenotype.
International journal of biological macromolecules - 1 Feb 2020
Zong Shuai, Li Jinglei, Ye Ziyang, Zhang Xinmiao, Yang Liu, Chen Xue, Ye Ming
Abstract excerpt
Therapeutic strategies that targeting tumor-associated macrophages (TAMs) reprogramming play a crucial role in ameliorating the immunosuppressive tumor microenvironment and boosting anti-tumor immune responses. In this study, we demonstrated that Lachnum polysaccharide (LEP) could work as an immunomodulator to reset TAMs from pro-tumor M2 to anti-tumor M1 phenotype. Mechanistically, LEP promoted Th1 polarization...
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