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Article

Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders: A Multivariable Mendelian Randomization Analysis.

JAMA psychiatry - 1 Feb 2021

Rosoff Daniel B, Smith George Davey, Lohoff Falk W

Abstract excerpt

Importance: Growing evidence suggests that prescription opioid use affects depression and anxiety disorders; however, observational studies are subject to confounding, making causal inference and determining the direction of these associations difficult. Objective: To investigate the potential bidirectional associations between the genetic liability for prescription opioid and other nonopioid pain medications and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33175090
DOI: 10.1001/jamapsychiatry.2020.3554
PMCID: PMC7658804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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