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Article

Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder.

JAMA psychiatry - 1 Mar 2026

Walker Alicia, Mitchell Brittany L, Lin Tian, Crouse Jacob J, Albiñana Clara, Yap Chloe X, Lynall Mary Ellen, Lind Penelope A, Cipriani Andrea, Byrne Enda M, Medland Sarah E, Martin Nicholas G, Taquet Maxime, Hickie Ian B, Wray Naomi R

Abstract excerpt

Importance: Antidepressant treatment remains a trial-and-error process: one-third of people with major depressive disorder (MDD) report inefficacy of first-line medications. Predictors of prescription patterns are needed to improve prescribing precision. Objective: To investigate phenotypic and genetic heterogeneity of MDD subgroups defined by antidepressant prescription patterns. Design, Setting, and...

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Identifiers

PMID: 41604195
DOI: 10.1001/jamapsychiatry.2025.4372
PMCID: PMC12853290

Genes

LY9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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