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Article

Genetically Predicted Use of Common Analgesics and Risk of Chronic Obstructive Pulmonary Disease: A Bidirectional Mendelian Randomization Study.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Chen Guojun, You Wanhui

Abstract excerpt

Background: Observational studies suggest a link between common analgesic use and chronic obstructive pulmonary disease (COPD), but causality is unclear. This study aimed to investigate the bidirectional causal relationship between the genetically predicted use of paracetamol, aspirin, and ibuprofen, and COPD risk using a two-sample Mendelian randomization (MR) approach. Methods: We performed a bidirectional MR...

Topics

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Acetaminophen
Analgesics
Analgesics, Non-Narcotic
Aspirin
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmacogenomic Variants

Pulmonary Disease, Chronic Obstructive

Risk Assessment

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Identifiers

PMID: 42199875
DOI: 10.2147/COPD.S586858
PMCID: PMC13199608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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