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Article

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.

Cell stem cell - 6 Mar 2014

Kats Lev M, Reschke Markus, Taulli Riccardo, Pozdnyakova Olga, Burgess Kerri, Bhargava Parul, Straley Kimberly, Karnik Rahul, Meissner Alexander, Small Donald, Su Shinsan M, Yen Katharine, Zhang Jiangwen, Pandolfi Pier Paolo

Abstract excerpt

Mutations in the metabolic enzymes isocitrate dehydrogenase-1 (IDH1) and IDH2 that produce the oncometabolite D-2-hydroxyglutarate (2-HG) occur frequently in human acute myeloid leukemia (AML). 2-HG modulates numerous biological pathways implicated in malignant transformation, but the contribution of mutant IDH proteins to maintenance and progression of AML in vivo is currently unknown. To answer this crucial...

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Source

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Identifiers

PMID: 24440599
DOI: 10.1016/j.stem.2013.12.016
PMCID: PMC4380188

Genes

IDH2
FLT3
IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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