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Mutant IDH1 cooperates with NPM1c or FLT3 ITD to drive distinct myeloid diseases and molecular outcomes

16 May 2025

Abstract excerpt

In human acute myeloid leukemia (AML), mutations of isocitrate dehydrogenase-1 ( IDH1 ) often co-occur with NPM1 mutations, and less frequently with FLT3 mutations. To investigate whether the effects of IDH1 mutation differ according to the specific co-occurring mutation, we generated two strains of double knock-in mutant mice. Idh1 R132H combined with Npm1c induced overt AML, whereas Idh1 R132H plus Flt3 ITD...

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PMID: 40377995
DOI: 10.1073/pnas.2415779122

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