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Article

Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control.

Molecular and cellular biology - 25 Jan 2021

Mills Christine A, Wang Xianxi, Bhatt Dhaval P, Grimsrud Paul A, Matson Jacob Peter, Lahiri Debojyoti, Burke Daniel J, Cook Jeanette Gowen, Hirschey Matthew D, Emanuele Michael J

Abstract excerpt

The ubiquitin-proteasome system is essential for cell cycle progression. Cyclin F is a cell cycle-regulated substrate adapter F-box protein for the Skp1, CUL1, and F-box protein (SCF) family of E3 ubiquitin ligases. Despite its importance in cell cycle progression, identifying cyclin F-bound SCF complex (SCFCyclin F) substrates has remained challenging. Since cyclin F overexpression rescues a yeast mutant in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33168699
DOI: 10.1128/MCB.00269-20
PMCID: PMC8093487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control.PMID 33168699Read ↗

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