Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclin F-Dependent Degradation of RBPJ Inhibits IDH1R132H-Mediated Tumorigenesis

25 Sept 2018

Abstract excerpt

Abstract Cyclin F is a substrate recognition subunit of Skp1-Cul1-F-box protein (SCF) E3 ubiquitin ligase complex. Although there have been reports describing the role of cyclin F in the genotoxic stress response, its function under conditions of altered metabolic homeostasis remain unexplored. Here we report that cyclin F is induced upon metabolic stress in a FOXO1-dependent manner. Under metabolic stress...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30254149
DOI: 10.1158/0008-5472.can-18-1772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Cyclin F-Dependent Degradation of RBPJ Inhibits IDH1R132H-Mediated TumorigenesisPMID 30254149Read ↗

E2F1 proteolysis via SCF‐cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibitionSemantic proximity Read ↗

Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control.Semantic proximity Read ↗

Cyclin F: A component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancerSemantic proximity Read ↗

Plk1 regulates mutant IDH1 enzyme activity and mutant IDH2 ubiquitination in mitosis.Semantic proximity Read ↗

The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic TransformationSemantic proximity Read ↗

GCDH Acetylation Orchestrates DNA Damage Response and Autophagy via Mitochondrial ROS to Suppress Hepatocellular Carcinoma ProgressionSemantic proximity Read ↗

Loss of FBXW7 Correlates with Increased IDH1 Expression in Glioma and Enhances IDH1-Mutant Cancer Cell Sensitivity to Radiation.Semantic proximity Read ↗

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.Semantic proximity Read ↗

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2Semantic proximity Read ↗

A conserved mitochondrial role for cyclin C in mediating oxidative stress-induced cell death in yeastSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.