Cyclin F disruption compromises placental development and affects normal cell cycle execution.

Abstract excerpt

Human cyclin F was originally isolated as a cDNA capable of suppressing the temperature sensitivity of a Saccharomyces cerevisiae cdc4-1 mutant. Its tightly regulated expression and high conservation in the evolutionary progression from amphibians to mammals suggest that it coordinates the timing of a critical cell cycle event. The fact that it contains an F box and can form an SCF (Skp1-Cul1/Cdc53-F-box) complex...

Topics

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• Cell Cycle
• Cyclins
• Embryonic and Fetal Development
• Fetal Death
• Placenta