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Article

Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation.

The Journal of biological chemistry - 6 Jul 2007

North Brian J, Verdin Eric

Abstract excerpt

Sirtuins are evolutionarily conserved NAD(+)-dependent deacetylases and ADP-ribosyltransferases involved in the regulation of cell division, apoptosis, DNA damage repair, genomic silencing, and longevity. Recent studies have focused on identifying target substrates for human sirtuin enzymatic activity, but little is known about processes that directly regulate their function. Here, we demonstrate that SIRT2 is...

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Source

Identifiers

PMID: 17488717
DOI: 10.1074/jbc.M702990200

Genes

SIRT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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