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Article

Interindividual differences in placental expression of the SLC22A2 (OCT2) gene: relationship to epigenetic variations in the 5'-upstream regulatory region.

Journal of pharmaceutical sciences - 1 Sept 2011

Saito Jumpei, Hirota Takeshi, Kikunaga Naomi, Otsubo Kenji, Ieiri Ichiro

Abstract excerpt

Organic cation transporters (OCTs) mediate the transport of organic cations and some drugs (e.g., metformin and cimetidine). OCT1, OCT2, and OCT3 are located in the imprinting cluster of the insulin-like growth factor 2 receptor. It has been reported that OCT1 and OCT3 show a biallelic expression, whereas OCT2 undergoes maternal imprinting in the human placenta; however, a loss of the imprinting of OCT2 has...

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PMID: 21523786
DOI: 10.1002/jps.22595

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