Article
24-hour rhythm of aquaporin-3 function in the epidermis is regulated by molecular clocks.
The Journal of investigative dermatology - 1 Jun 2014
Matsunaga Naoya, Itcho Kazufumi, Hamamura Kengo, Ikeda Eriko, Ikeyama Hisako, Furuichi Yoko, Watanabe Miyako, Koyanagi Satoru, Ohdo Shigehiro
Abstract excerpt
Aquaporin 3 (AQP3) is located in the basal layer of the epidermis and regulates biological functions of skin such as water content and trans-epidermal water loss. A recent study showed that the biological function of skin exhibits a 24-hour rhythm, but the molecular mechanism of the variation remains poorly understood. Here we show that mice mutated in the core clock component CLOCK (Clk/Clk) show decreased...
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