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Article

Gain-of-function variants in NLRP1 protect against the development of diabetic kidney disease: NLRP1 inflammasome role in metabolic stress sensing?

Clinical immunology (Orlando, Fla.) - 1 Feb 2018

Soares Jaine L S, Fernandes Fernanda Pereira, Patente Thiago Andrade, Monteiro Maria B, Parisi Maria C, Giannella-Neto Daniel, Corrêa-Giannella Maria L, Pontillo Alessandra

Abstract excerpt

Although inflammasome plays a well-known role in animal models of renal injury, limited studies in humans are available, and its participation in diabetic kidney disease (DKD) remains unknown. Aim of this study was to elucidate the contribution of inflammasome genetics in the development of DKD in type-1 diabetes (T1D). The association of functional variants in inflammasome genes with DKD was assessed by...

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Share to Apoptosis Regulatory Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29031829
DOI: 10.1016/j.clim.2017.10.003

Genes

NLRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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