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Article

Combined polymorphisms in genes encoding the inflammasome components NLRP3 and CARD8 confer risk of ischemic stroke in men.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Aug 2020

Lv Jie, Jiang Xiaoshan, Zhang Jing, Peng Xianghui, Lin Hongmei

Abstract excerpt

INTRODUCTION: Previous studies have reported the involvement of nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome in the inflammatory activation and pathophysiology of Ischemic Stroke (IS). Variations in genes encoding the constituent proteins of NLRP3 inflammasome can alter the risk of IS. OBJECTIVE: We investigated the role of the NLRP3 inflammasome in the pathogenesis of IS by...

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Identifiers

PMID: 32689633
DOI: 10.1016/j.jstrokecerebrovasdis.2020.104874

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