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Article

Role of the NLRP3 inflammasome in diabetes and its complications (Review)

19 Aug 2025

Abstract excerpt

Diabetes and its complications are systemic metabolic disorders triggered by chronic hyperglycemia, with the NOD‑like receptor family pyrin domain‑containing 3 (NLRP3) inflammasome carrying out a central role in disease progression. Activation of the NLRP3 inflammasome is involved not only in the onset of diabetes but also in its complications, including cardiovascular disease, nephropathy and retinopathy. The...

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PMID: 40849818
DOI: 10.3892/mmr.2025.13657

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