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Article

Experimentally based structural model of Yih1 provides insight into its function in controlling the key translational regulator Gcn2.

FEBS letters - 1 Feb 2021

Harjes Elena, Jameson Geoffrey B, Tu Yi-Hsuan, Burr Natalie, Loo Trevor S, Goroncy Alexander K, Edwards Patrick J B, Harjes Stefan, Munro Ben, Göbl Christoph, Sattlegger Evelyn, Norris Gillian E

Abstract excerpt

Yeast impact homolog 1 (Yih1), or IMPACT in mammals, is part of a conserved regulatory module controlling the activity of General Control Nonderepressible 2 (Gcn2), a protein kinase that regulates protein synthesis. Yih1/IMPACT is implicated not only in many essential cellular processes, such as neuronal development, immune system regulation and the cell cycle, but also in cancer. Gcn2 must bind to Gcn1 in order...

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Identifiers

PMID: 33156522
DOI: 10.1002/1873-3468.13990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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