Article
Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.
The Journal of clinical investigation - 15 Sept 2023
Yu Zhi, Fidler Trevor P, Ruan Yunfeng, Vlasschaert Caitlyn, Nakao Tetsushi, Uddin Md Mesbah, Mack Taralynn, Niroula Abhishek, Heimlich J Brett, Zekavat Seyedeh M, Gibson Christopher J, Griffin Gabriel K, Wang Yuxuan, Peloso Gina M, Heard-Costa Nancy, Levy Daniel, Vasan Ramachandran S, Aguet François, Ardlie Kristin G, Taylor Kent D, Rich Stephen S, Rotter Jerome I, Libby Peter, Jaiswal Siddhartha, Ebert Benjamin L, Bick Alexander G, Tall Alan R, Natarajan Pradeep
Abstract excerpt
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVDs), putatively via inflammasome activation. We pursued an inflammatory gene modifier scan for CHIP-associated CVD risk among 424,651 UK Biobank participants. We identified CHIP using whole-exome sequencing data of blood DNA and modeled as a composite, considering all driver genes together, as...
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