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Article

Salpingectomy in individuals at high risk for tubo-ovarian cancer: consensus and precaution.

American journal of obstetrics and gynecology - 1 Apr 2026

Wilke Roni Nitecki, Pennington Kathryn P, Gootzen Tamar A, Steenbeek Miranda P, de Hullu Joanne A, Long Kara C, Blank Stephanie V, Swisher Elizabeth M, Lu Karen H, Norquist Barbara

Abstract excerpt

Tubo-ovarian carcinoma, particularly high-grade serous carcinoma, is one of the most lethal gynecologic malignancies, largely due to its late-stage diagnosis and lack of effective screening strategies. For individuals with hereditary pathogenic variants in genes associated with ovarian cancer such as BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2, and Lynch syndrome-associated genes, the National Comprehensive Cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41183726
DOI: 10.1016/j.ajog.2025.10.044

Genes

BRCA1
BRCA2
BRIP1
PALB2
RAD51C
RAD51D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Salpingectomy in individuals at high risk for tubo-ovarian cancer: consensus and precaution.PMID 41183726Read ↗

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Contemporary risk assessment and risk-reducing strategies for tubo-ovarian cancer in women with BRCA pathogenic variants.Semantic proximity Read ↗

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Early salpingectomy (TUbectomy) with delayed oophorectomy to improve quality of life as alternative for risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers (TUBA study): a prospective non-randomised multicentre study.Semantic proximity Read ↗

Salpingectomy for the Risk Reduction of Ovarian Cancer: Is It Time for a Salpingectomy-alone Approach?Semantic proximity Read ↗

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Risk-Reducing Bilateral Salpingo-Oophorectomy for Ovarian Cancer: A Review and Clinical Guide for Hereditary Predisposition Genes.Semantic proximity Read ↗

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