High-Grade Serous Carcinoma at Risk-Reducing Salpingo-Oophorectomy in Asymptomatic Carriers of BRCA1/2 Pathogenic Variants: Prevalence and Clinical Factors.

doi:10.1200/JCO.22.01237

Article

High-Grade Serous Carcinoma at Risk-Reducing Salpingo-Oophorectomy in Asymptomatic Carriers of BRCA1/2 Pathogenic Variants: Prevalence and Clinical Factors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2023

Stroot Iris A S, Brouwer Jan, Bart Joost, Hollema Harry, Stommel-Jenner Denise J, Wagner Marise M, van Doorn Helena C, de Hullu Joanne A, Gaarenstroom Katja N, Beurden Marc, van Lonkhuijzen Luc R C W, Slangen Brigitte F M, Zweemer Ronald P, Gómez Garcia Encarna B, Ausems Margreet G E M, Boere Ingrid A, van Engelen Klaartje, van Asperen Christi J, Schmidt Marjanka K, Wevers Marijke R, de Bock Geertruida H, Mourits Marian J E

Abstract excerpt

PURPOSE: To investigate the prevalence of and clinical factors associated with high-grade serous carcinoma (HGSC) at risk-reducing salpingo-oophorectomy (RRSO) in asymptomatic BRCA1/2-pathogenic variant (PV) carriers. PATIENTS AND METHODS: We included BRCA1/2-PV carriers who underwent RRSO between 1995 and 2018 from the Hereditary Breast and Ovarian cancer in the Netherlands study. All pathology reports were...

Topics

Female
Humans
Salpingo-oophorectomy
BRCA1 Protein
BRCA2 Protein
Prevalence
Mutation
Genetic Predisposition to Disease

High-Grade Serous Carcinoma at Risk-Reducing Salpingo-Oophorectomy in Asymptomatic Carriers of BRCA1/2 Pathogenic Variants: Prevalence and Clinical Factors.

Abstract excerpt

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