Occult ovarian cancers identified at risk-reducing salpingo-oophorectomy in a prospective cohort of BRCA1/2 mutation carriers.

doi:10.1007/s10549-010-0799-x

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Article

Occult ovarian cancers identified at risk-reducing salpingo-oophorectomy in a prospective cohort of BRCA1/2 mutation carriers.

Breast cancer research and treatment - 1 Nov 2010

Domchek Susan M, Friebel Tara M, Garber Judy E, Isaacs Claudine, Matloff Ellen, Eeles Rosalind, Evans D Gareth, Rubinstein Wendy, Singer Christian F, Rubin Stephen, Lynch Henry T, Daly Mary B, Weitzel Jeffrey, Ganz Patricia A, Pichert Gabriella, Olopade Olufunmilayo I, Tomlinson Gail, Tung Nadine, Blum Joanne L, Couch Fergus, Rebbeck Timothy R

Abstract excerpt

Risk-reducing salpingo-oophorectomy (RRSO) is widely used for cancer risk reduction in BRCA1 or BRCA2 (BRCA1/2) mutation carriers. Occult ovarian/fallopian tube cancers (OOC) detected at the time of RRSO have been reported in several studies with wide variability in reported prevalence. We estimated the prevalence of OOC in a prospective cohort of 647 BRCA1/2 mutation carriers from 18 centers (PROSE consortium)...

Topics

Adult
Aged
BRCA1 Protein
BRCA2 Protein
Europe
Fallopian Tube Neoplasms
Female
Genetic Predisposition to Disease
Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Middle Aged

Mutation

Neoplasm Staging

North America

Ovarian Neoplasms

Ovariectomy

Prevalence

Primary Prevention

Source

Open in PubMed Open full text

Identifiers

PMID: 20180014
DOI: 10.1007/s10549-010-0799-x
PMCID: PMC2949487

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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