Article
Efficacy of risk-reducing salpingo-oophorectomy in BRCA1-2 variants and clinical outcomes of follow-up in patients with isolated serous tubal intraepithelial carcinoma (STIC).
Gynecologic oncology - 1 Nov 2021
Saccardi Carlo, Zovato Stefania, Spagnol Giulia, Bonaldo Giulio, Marchetti Matteo, Alessandrini Lara, Tognazzo Silvia, Guerriero Angela, Vitagliano Amerigo, Laganà Antonio Simone, Noventa Marco
Abstract excerpt
OBJECTIVE: Serous tubal intraepithelial carcinoma (STIC) is currently considered the precursor lesion of pelvic high-grade serous carcinoma. The management of STIC diagnosed after risk-reducing salpingo-oophorectomy (RRSO) in women with BRCA1-2 variants remains unclear. The aim of our study was to evaluate the incidence of STIC, serous tubal intraepithelial lesions (STIL) and occult invasive cancer (OC) and to...
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