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Article

Contemporary risk assessment and risk-reducing strategies for tubo-ovarian cancer in women with BRCA pathogenic variants.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jun 2026

Viveros-Carreño David, Beshar Isabel, Agustí Nuria, Murthy Ananya, Mora-Soto Nathalia, Iniesta Maria D, Barajas Karla, Melamed Alexander, Rauh-Hain J Alejandro, Wilke Roni Nitecki

Abstract excerpt

Tubo-ovarian cancer represents the most lethal gynecologic malignancy, and its burden is compounded by the absence of effective screening and the substantial lifetime risk carried by women with germline BRCA1 or BRCA2 pathogenic variants. While risk-reducing salpingo-oophorectomy remains the standard for prevention, conferring reduction in tubo-ovarian cancer risk and improved overall survival, it also induces...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42056783
DOI: 10.1016/j.ijgc.2026.104676
PMCID: PMC13371952

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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Risk-reducing salpingectomy: Let us be opportunistic.Semantic proximity Read ↗

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