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Contemporary risk assessment and risk-reducing strategies for tubo-ovarian cancer in women with BRCA pathogenic variants.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jun 2026

Viveros-Carreño David, Beshar Isabel, Agustí Nuria, Murthy Ananya, Mora-Soto Nathalia, Iniesta Maria D, Barajas Karla, Melamed Alexander, Rauh-Hain J Alejandro, Wilke Roni Nitecki

Abstract excerpt

Tubo-ovarian cancer represents the most lethal gynecologic malignancy, and its burden is compounded by the absence of effective screening and the substantial lifetime risk carried by women with germline BRCA1 or BRCA2 pathogenic variants. While risk-reducing salpingo-oophorectomy remains the standard for prevention, conferring reduction in tubo-ovarian cancer risk and improved overall survival, it also induces...

Topics

Humans
Female
Risk Assessment
Ovarian Neoplasms
Fallopian Tube Neoplasms
Risk Reduction Behavior
Salpingo-oophorectomy
BRCA2 Protein
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

BRCA1 Protein

Germ-Line Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42056783
DOI: 10.1016/j.ijgc.2026.104676
PMCID: PMC13371952

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Contemporary risk assessment and risk-reducing strategies for tubo-ovarian cancer in women with BRCA pathogenic variants.PMID 42056783Read ↗

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