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Article

Reversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli.

Journal of bacteriology - 1 Oct 2015

Soparkar Ketaki, Kinana Alfred D, Weeks Jon W, Morrison Keith D, Nikaido Hiroshi, Misra Rajeev

Abstract excerpt

UNLABELLED: The AcrB protein of Escherichia coli, together with TolC and AcrA, forms a contiguous envelope conduit for the capture and extrusion of diverse antibiotics and cellular metabolites. In this study, we sought to expand our knowledge of AcrB by conducting genetic and functional analyses. We began with an AcrB mutant bearing an F610A substitution in the drug binding pocket and obtained second-site...

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Source

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Identifiers

PMID: 26240069
DOI: 10.1128/JB.00547-15
PMCID: PMC4573724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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