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Article

Mutation-driven alterations in the AcrB efflux pump modulate antibiotic resistance in Klebsiella pneumoniae.

The Journal of antimicrobial chemotherapy - 4 Aug 2026

Dinata Roy, Baindara Piyush, Chakraborty Sourav, Mondal Safikureshi, Mandal Santi M

Abstract excerpt

OBJECTIVES: To investigate the global prevalence of the acrB efflux transporter among antibiotic resistance genes (ARGs) in Klebsiella pneumoniae and to determine how mutations within AcrB drug-binding pockets influence structural stability and antibiotic interactions. METHODS: A global genomic analysis of 42 ARGs reported in K. pneumoniae isolates worldwide was performed to identify the prominence of acrB. A...

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Identifiers

PMID: 42554209
DOI: 10.1093/jac/dkag270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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