Article
Determining and overcoming resistance to HIV protease inhibitors.
Current drug targets. Infectious disorders - 1 Jun 2004
Prejdová Jana, Soucek Milan, Konvalinka Jan
Abstract excerpt
HIV protease represents a major target for development of antiviral therapeutics. The introduction of HIV protease (PR) inhibitors (PIs) to clinical practice and the application of highly active antiretroviral therapy resulted in decreased mortality and prolonged life expectancy of HIV-positive patients. However, the high polymorphism of HIV leads to rapid selection of viral variants resistant towards the...
Topics
- Dimerization
- Drug Design
- Drug Resistance, Viral
- Genotype
- HIV
- HIV Infections
- HIV Protease Inhibitors
- Humans
- Phenotype
- Virus Replication