Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.

doi:10.1007/s00401-018-1905-0

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Article

Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.

Acta neuropathologica - 1 Nov 2018

Stichel Damian, Ebrahimi Azadeh, Reuss David, Schrimpf Daniel, Ono Takahiro, Shirahata Mitsuaki, Reifenberger Guido, Weller Michael, Hänggi Daniel, Wick Wolfgang, Herold-Mende Christel, Westphal Manfred, Brandner Sebastian, Pfister Stefan M, Capper David, Sahm Felix, von Deimling Andreas

Abstract excerpt

EGFR amplification (EGFRamp), the combination of gain of chromosome 7 and loss of chromosome 10 (7+/10-), and TERT promoter mutation (pTERTmut) are alterations frequently observed in adult IDH-wild-type (IDHwt) glioblastoma (GBM). In the absence of endothelial proliferation and/or necrosis, these alterations currently are considered to serve as a surrogate for upgrading IDHwt diffuse or anaplastic astrocytoma to...

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PMID: 30187121
DOI: 10.1007/s00401-018-1905-0

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