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Article

Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.

Genetics - 1 Nov 2013

Yu Tian, Bachman John, Lai Zhi-Chun

Abstract excerpt

The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24026096
DOI: 10.1534/genetics.113.156372
PMCID: PMC3813850

Genes

LATS1
LATS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.PMID 24026096Read ↗

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Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.Semantic proximity Read ↗

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