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Article

Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts.

Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2018

DuBose Amanda J, Lichtenstein Stephen T, Petrash Noreen M, Erdos Michael R, Gordon Leslie B, Collins Francis S

Abstract excerpt

LMNA encodes the A-type lamins that are part of the nuclear scaffold. Mutations in LMNA can cause a variety of disorders called laminopathies, including Hutchinson-Gilford progeria syndrome (HGPS), atypical Werner syndrome, and Emery-Dreifuss muscular dystrophy. Previous work has shown that treatment of HGPS cells with the mTOR inhibitor rapamycin or with the rapamycin analog everolimus corrects several of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29581305
DOI: 10.1073/pnas.1802811115
PMCID: PMC5910873

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Research trail→

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Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts.PMID 29581305Read ↗

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Hutchinson-Gilford Progeria paves the way for novel targeted anti-aging therapies.Semantic proximity Read ↗

MG132 induces progerin clearance and improves disease phenotypes in fibroblasts of patients affected with Hutchinson-Gilford Progeria-like syndromesSemantic proximity Read ↗

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