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Article

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.

PloS one - 1 Jan 2016

Gabriel Diana, Gordon Leslie B, Djabali Karima

Abstract excerpt

Hutchinson-Gilford syndrome (HGPS, OMIM 176670, a rare premature aging disorder that leads to death at an average age of 14.7 years due to myocardial infarction or stroke, is caused by mutations in the LMNA gene. Lamins help maintain the shape and stability of the nuclear envelope in addition to regulating DNA replication, DNA transcription, proliferation and differentiation. The LMNA mutation results in the...

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Identifiers

PMID: 28033363
DOI: 10.1371/journal.pone.0168988
PMCID: PMC5199099

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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