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Article

Differential transcript usage in the Parkinson’s disease brain

2 Nov 2020

Abstract excerpt

Studies of differential gene expression have identified several molecular signatures and pathways associated with Parkinson's disease (PD). The role of isoform switches and differential transcript usage (DTU) remains, however, unexplored. Here, we report the first genome-wide study of DTU in PD. We performed RNA sequencing following ribosomal RNA depletion in prefrontal cortex samples of 49 individuals from two...

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PMID: 33137089
DOI: 10.1371/journal.pgen.1009182

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