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Article

Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9.

Biochimie - 1 Jan 2021

Noori Ali-Reza, Tashakor Amin, Nikkhah Maryam, Eriksson Leif A, Hosseinkhani Saman, Fearnhead Howard O

Abstract excerpt

Split luciferase complementary assay has been used to investigate the effect of WD domain deletion on Apaf-1 oligomerization. Apaf-1 is an adaptor molecule in formation of apoptosome that activates caspase-9, an activation that is a key event in the mitochondrial cell death pathway. Structural studies suggest that normally Apaf-1 is held in an inactive conformation by intramolecular interactions between Apaf-1's...

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Identifiers

PMID: 33132160
DOI: 10.1016/j.biochi.2020.10.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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