Article
Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
Molecular cell - 1 Jun 1998
Srinivasula S M, Ahmad M, Fernandes-Alnemri T, Alnemri E S
Abstract excerpt
Activation of procaspase-9 by Apaf-1 in the cytochrome c/dATP-dependent pathway requires proteolytic cleavage to generate the mature caspase molecule. To elucidate the mechanism of activation of procaspase-9 by Apaf-1, we designed an in vitro Apaf-1-procaspase-9 activation system using recombinan...
Topics
- Adenosine Triphosphate
- Apoptosis
- Apoptotic Protease-Activating Factor 1
- Binding Sites
- Biopolymers
- Caspase 3
- Caspase 6
- Caspase 7
- Caspase 9
- Caspases
- Catalysis
- Cysteine Endopeptidases
- Cytochrome c Group
- Dimerization
- Enzyme Activation
- Enzyme Precursors
- Humans
- Mutation