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Article

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.

Molecular cell - 1 Jun 1998

Srinivasula S M, Ahmad M, Fernandes-Alnemri T, Alnemri E S

Abstract excerpt

Activation of procaspase-9 by Apaf-1 in the cytochrome c/dATP-dependent pathway requires proteolytic cleavage to generate the mature caspase molecule. To elucidate the mechanism of activation of procaspase-9 by Apaf-1, we designed an in vitro Apaf-1-procaspase-9 activation system using recombinant components. Here, we show that deletion of the Apaf-1 WD-40 repeats makes Apaf-1 constitutively active and capable of...

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PMID: 9651578
DOI: 10.1016/s1097-2765(00)80095-7

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