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Article

ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity.

Cell death and differentiation - 1 Jan 2007

Srivastava M, Scherr H, Lackey M, Xu D, Chen Z, Lu J, Bergmann A

Abstract excerpt

In mammals and Drosophila, apoptotic caspases are under positive control of the CED-4-like proteins Apaf-1 and ARK, respectively. In an EMS-mutagenesis screen, we isolated 33 ark mutants as recessive suppressors of hid-induced apoptosis. The ark mutants are loss-of-function alleles characterized by reduced developmental apoptosis. Using the phenotypic series of these alleles, we identified helical domain I in the...

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Identifiers

PMID: 16645639
DOI: 10.1038/sj.cdd.4401931
PMCID: PMC2502064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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