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Article

A kinase-independent function of Ask1 in caspase-independent cell death.

The Journal of biological chemistry - 28 Sept 2001

Charette S J, Lambert H, Landry J

Abstract excerpt

Ask1 (apoptosis signal-regulating kinase 1) is activated as a consequence of cell exposure to a variety of stresses and can then initiate apoptosis. A known pathway of apoptosis downstream of Ask1 involves the activation of the stress-activated protein kinases, the release of cytochrome c from mitochondria, the activation of caspases, and the fragmentation of nuclei. Here, we characterized a novel mechanism of...

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Identifiers

PMID: 11493600
DOI: 10.1074/jbc.C100340200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A kinase-independent function of Ask1 in caspase-independent cell death.PMID 11493600Read ↗

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Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins.Semantic proximity Read ↗

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