Article
A kinase-independent function of Ask1 in caspase-independent cell death.
The Journal of biological chemistry - 28 Sept 2001
Charette S J, Lambert H, Landry J
Abstract excerpt
Ask1 (apoptosis signal-regulating kinase 1) is activated as a consequence of cell exposure to a variety of stresses and can then initiate apoptosis. A known pathway of apoptosis downstream of Ask1 involves the activation of the stress-activated protein kinases, the release of cytochrome c from mitochondria, the activation of caspases, and the fragmentation of nuclei. Here, we characterized a novel mechanism of...
Topics
- Adaptor Proteins, Signal Transducing
- Arabidopsis Proteins
- Carrier Proteins
- Caspases
- Cell Death
- Cell Line
- Cell Nucleus
- Co-Repressor Proteins
- DNA Fragmentation
- Gene Deletion
- Humans
- Intracellular Signaling Peptides and Proteins
- Microscopy, Fluorescence
- Molecular Chaperones
- Mutation
- Nuclear Proteins
- Plant Proteins
- Plasmids