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Article

Role of the salt bridge between glutamate 546 and arginine 907 in preservation of autoinhibited form of Apaf-1.

International journal of biological macromolecules - 1 Nov 2015

Shakeri Raheleh, Hosseinkhani Saman, Los Marek J, Davoodi Jamshid, Jain Mayur V, Cieślar-Pobuda Artur, Rafat Mehrdad, Ardestani Sussan Kaboudanian

Abstract excerpt

Apaf-1, the key element of apoptotic mitochondrial pathway, normally exists in an auto-inhibited form inside the cytosol. WRD-domain of Apaf-1 has a critical role in the preservation of auto-inhibited form; however the underlying mechanism is unclear. It seems the salt bridges between WRD and NOD...

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Identifiers

PMID: 26277751
DOI: 10.1016/j.ijbiomac.2015.08.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26277751-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Role of the salt bridge between glutamate 546 and arginine 907 in preservation of autoinhibited form of Apaf-1.PMID 26277751Read ↗

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