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Article

OGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage.

Iranian biomedical journal - 1 Jan 2021

Miglani Kanika, Kumar Sunil, Yadav Anita, Aggarwal Neeraj, Gupta Ranjan

Abstract excerpt

Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2'-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this study was to examine...

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Identifiers

PMID: 33129239
DOI: 10.29252/ibj.25.1.47
PMCID: PMC7748119

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