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Article

S-Nitrosylation of Akt by organic nitrate delays revascularization and the recovery of cardiac function in mice following myocardial infarction.

Journal of cellular and molecular medicine - 1 Jan 2021

Li Xiao-Yan, Zhang Hong-Ming, An Gui-Peng, Liu Mo-Yan, Han Shu-Fang, Jin Qun, Song Ying, Lin Yi-Meng, Dong Bo, Wang Shuang-Xi, Meng Ling-Bo

Abstract excerpt

The effects of long-term nitrate therapy are compromised due to protein S-Nitrosylation, which is mediated by nitric oxide (NO). This study is to determine the role of Akt S-Nitrosylation in the recovery of heart functions after ischaemia. In recombinant Akt protein and in HEK293 cells, NO donor decreased Akt activity and induced Akt S-Nitrosylation, but was abolished if Akt protein was mutated by replacing...

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Identifiers

PMID: 33128338
DOI: 10.1111/jcmm.15263
PMCID: PMC7810919

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