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Article

Tissue engineering with targeted delivery of nanotized S-nitrosyl mutant of NEMO ameliorates myocardial infarction.

Nanomedicine (London, England) - 1 May 2025

Kar Abhik, Gupta Soumyadeep, Matilal Arkapravo, Sarkar Sagartirtha

Abstract excerpt

BACKGROUND: Myocardial infarction (MI) is characterized by an elevated nitrosative and hypoxic microenvironment due to reduced coronary blood flow. NEMO (IKKγ) regulates the formation of the IKK holo-complex to activate NFκB-p65 signaling. This study reports successful restoration of MI through cardiomyocyte-targeted nanotized S-nitrosyl mutant of NEMO under elevated nitrosative stress. METHODS: The MI model was...

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Identifiers

PMID: 40235354
DOI: 10.1080/17435889.2025.2491989
PMCID: PMC12068353

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HDAC1

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