Article
S-Nitrosoglutathione Reductase Deficiency Enhances the Proliferative Expansion of Adult Heart Progenitors and Myocytes Post Myocardial Infarction.
Journal of the American Heart Association - 15 Jul 2015
Hatzistergos Konstantinos E, Paulino Ellena C, Dulce Raul A, Takeuchi Lauro M, Bellio Michael A, Kulandavelu Shathiyah, Cao Yenong, Balkan Wayne, Kanashiro-Takeuchi Rosemeire M, Hare Joshua M
Abstract excerpt
BACKGROUND: Mammalian heart regenerative activity is lost before adulthood but increases after cardiac injury. Cardiac repair mechanisms, which involve both endogenous cardiac stem cells (CSCs) and cardiomyocyte cell-cycle reentry, are inadequate to achieve full recovery after myocardial infarction (MI). Mice deficient in S-nitrosoglutathione reductase (GSNOR(-⁄-)), an enzyme regulating S-nitrosothiol turnover,...
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