Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.

The Journal of biological chemistry - 4 Mar 2005

Yasukawa Takashi, Tokunaga Eriko, Ota Hidetaka, Sugita Hiroki, Martyn J A Jeevendra, Kaneki Masao

Abstract excerpt

Inducible nitric-oxide synthase (iNOS) has been implicated in many human diseases including insulin resistance. However, how iNOS causes or exacerbates insulin resistance remains largely unknown. Protein S-nitrosylation is now recognized as a prototype of a redox-dependent, cGMP-independent signaling component that mediates a variety of actions of nitric oxide (NO). Here we describe the mechanism of inactivation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Adipocytes
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Nitric Oxide

Share to Nitric Oxide Synthase

Share to Nitric Oxide Synthase Type II

Share to Nitrogen

Source

Identifiers

PMID: 15632167
DOI: 10.1074/jbc.M411871200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.PMID 15632167Read ↗

S-Nitrosylation of Akt by organic nitrate delays revascularization and the recovery of cardiac function in mice following myocardial infarction.Semantic proximity Read ↗

Critical cysteines in Akt1 regulate its activity and proteasomal degradation: implications for neurodegenerative diseases.Semantic proximity Read ↗

S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy.Semantic proximity Read ↗

Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway.Semantic proximity Read ↗

Cys340Ser Mutation Abolishing S-Nitrosylation Drives GRK2 Mitochondrial Localization and Dysfunction.Semantic proximity Read ↗

Nitrosative stress leads to protein glutathiolation, increased s-nitrosation, and up-regulation of peroxiredoxins in the heart.Semantic proximity Read ↗

S-nitrosylation of ERK inhibits ERK phosphorylation and induces apoptosis.Semantic proximity Read ↗

Tyr740 and Tyr751 residues of platelet-derived growth factor beta receptor are responsible for the redox regulation of phosphatase and tensin homolog in the cells stimulated with platelet-derived growth factor.Semantic proximity Read ↗

Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.Semantic proximity Read ↗

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt.Semantic proximity Read ↗

Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging.Semantic proximity Read ↗

S-nitrosylation inhibits pannexin 1 channel function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.