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Article

Endothelial nitric oxide synthase is involved in calcium-induced Akt signaling in mouse skeletal muscle.

Nitric oxide : biology and chemistry - 1 Jan 2000

Drenning Jason A, Lira Vitor A, Soltow Quinlyn A, Canon Claire N, Valera Lauren M, Brown Dana L, Criswell David S

Abstract excerpt

We hypothesized that targeted mutation of the endothelial nitric oxide synthase (eNOS) gene would reduce Akt-related signaling events in skeletal muscle cells, compared to wild type (WT) controls. Results show that slow myosin heavy chain (type I/beta) expression and the abundance of slow-twitch fibers are reduced in plantaris muscle of eNOS(-/-) mice, compared to WT. Further, basal phosphorylation of Akt (p-Akt...

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Identifiers

PMID: 19682597
DOI: 10.1016/j.niox.2009.08.001

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