Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity.

doi:10.1016/j.cell.2020.09.058

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity.

Cell - 29 Oct 2020

Kalafati Lydia, Kourtzelis Ioannis, Schulte-Schrepping Jonas, Li Xiaofei, Hatzioannou Aikaterini, Grinenko Tatyana, Hagag Eman, Sinha Anupam, Has Canan, Dietz Sevina, de Jesus Domingues Antonio Miguel, Nati Marina, Sormendi Sundary, Neuwirth Ales, Chatzigeorgiou Antonios, Ziogas Athanasios, Lesche Mathias, Dahl Andreas, Henry Ian, Subramanian Pallavi, Wielockx Ben, Murray Peter, Mirtschink Peter, Chung Kyoung-Jin, Schultze Joachim L, Netea Mihai G, Hajishengallis George, Verginis Panayotis, Mitroulis Ioannis, Chavakis Triantafyllos

Abstract excerpt

Trained innate immunity, induced via modulation of mature myeloid cells or their bone marrow progenitors, mediates sustained increased responsiveness to secondary challenges. Here, we investigated whether anti-tumor immunity can be enhanced through induction of trained immunity. Pre-treatment of mice with β-glucan, a fungal-derived prototypical agonist of trained immunity, resulted in diminished tumor growth. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptive Immunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adoptive Transfer

Share to beta-Glucans

Share to Granulocytes

Share to Interferon Type I

Share to Monocytes

Share to Neutrophils

Share to Receptor, Interferon alpha-beta

Source

Open in PubMed Open full text

Identifiers

PMID: 33125892
DOI: 10.1016/j.cell.2020.09.058
PMCID: PMC7599076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity.PMID 33125892Read ↗

The mechanisms and cross-protection of trained innate immunitySemantic proximity Read ↗

Trained immunity as a novel therapeutic strategySemantic proximity Read ↗

The causes and consequences of trained immunity in myeloid cellsSemantic proximity Read ↗

High-throughput screen identifies non inflammatory small molecule inducers of trained immunitySemantic proximity Read ↗

Forged in the fire: Lasting impacts of inflammation on hematopoietic progenitorsSemantic proximity Read ↗

β-glucan induced trained immunity enhances antibody levels in a vaccination model in miceSemantic proximity Read ↗

β-Glucan Reprograms Neutrophils to Induce Disease Tolerance Against Influenza A VirusSemantic proximity Read ↗

Hematopoietic stem and progenitor cells as a reservoir for trained immunitySemantic proximity Read ↗

β-Glucan-Induced Trained Immunity in DogsSemantic proximity Read ↗

Trained Immunity for Personalized Cancer Immunotherapy: Current Knowledge and Future OpportunitiesSemantic proximity Read ↗

The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory DisordersSemantic proximity Read ↗

Immunometabolic circuits in trained immunitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.