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Article

Trained Immunity for Personalized Cancer Immunotherapy: Current Knowledge and Future Opportunities

10 Jan 2020

Abstract excerpt

Memory formation, guided by microbial ligands, has been reported for innate immune cells. Epigenetic imprinting plays an important role herein, involving histone modification after pathogen-/danger-associated molecular patterns (PAMPs/DAMPs) recognition by pattern recognition receptors (PRRs). Such "trained immunity" affects not only the nominal target pathogen, yet also non-related targets that may be...

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PMID: 31998254
DOI: 10.3389/fmicb.2019.02924

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