Article
Evaluating genotype imputation pipeline for ultra-low coverage ancient genomes.
Scientific reports - 29 Oct 2020
Hui Ruoyun, D'Atanasio Eugenia, Cassidy Lara M, Scheib Christiana L, Kivisild Toomas
Abstract excerpt
Although ancient DNA data have become increasingly more important in studies about past populations, it is often not feasible or practical to obtain high coverage genomes from poorly preserved samples. While methods of accurate genotype imputation from > 1 × coverage data have recently become a routine, a large proportion of ancient samples remain unusable for downstream analyses due to their low coverage. Here,...
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