Article
Imputation of ancient human genomes.
Nature communications - 20 Jun 2023
Sousa da Mota Bárbara, Rubinacci Simone, Cruz Dávalos Diana Ivette, G Amorim Carlos Eduardo, Sikora Martin, Johannsen Niels N, Szmyt Marzena H, Włodarczak Piotr, Szczepanek Anita, Przybyła Marcin M, Schroeder Hannes, Allentoft Morten E, Willerslev Eske, Malaspinas Anna-Sapfo, Delaneau Olivier
Abstract excerpt
Due to postmortem DNA degradation and microbial colonization, most ancient genomes have low depth of coverage, hindering genotype calling. Genotype imputation can improve genotyping accuracy for low-coverage genomes. However, it is unknown how accurate ancient DNA imputation is and whether imputation introduces bias to downstream analyses. Here we re-sequence an ancient trio (mother, father, son) and downsample...
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