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Article

8q24 clear cell renal cell carcinoma germline variant is associated with VHL mutation status and clinical aggressiveness.

BMC urology - 29 Oct 2020

Eckel-Passow Jeanette E, Yan Huihuang, Kosel Matthew L, Serie Daniel, Decker Paul A, Jenkins Robert B, Costello Brian, Leibovich Bradley, Ho Thai H, Parker Alexander

Abstract excerpt

BACKGROUND: The four most commonly-mutated genes in clear cell renal cell carcinoma (ccRCC) tumors are BAP1, PBRM1, SETD2 and VHL. And, there are currently 14 known RCC germline variants that have been reproducibly shown to be associated with RCC risk. However, the association of germline genetics with tumor genetics and clinical aggressiveness are unknown. METHODS: We analyzed 420 ccRCC patients from The Cancer...

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Identifiers

PMID: 33121461
DOI: 10.1186/s12894-020-00745-9
PMCID: PMC7597051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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