Article

8q24 Clear Cell Renal Cell Carcinoma Germline Variant is Associated with VHL Mutation Status and Clinical Aggressiveness

2020-10-22

Abstract excerpt

<h4>Background: </h4> The four most commonly-mutated genes in clear cell renal cell carcinoma (ccRCC) tumors are BAP1 , PBRM1 , SETD2 and VHL . And, there are currently 14 known RCC germline variants that have been reproducibly shown to be associated with RCC risk. However, the association of germline genetics with tumor genetics and clinical aggressiveness are unknown. <h4>Methods: </h4>: We analyzed 420 ccRCC pa...

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Literature Corpus work: e0b08ed9-53cb-5a11-9d2d-c3fe9a758b61
DOI: 10.21203/rs.3.rs-48012/v3

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