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Article

Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations.

Mathematical biosciences and engineering : MBE - 16 Jul 2020

Morris Bethan, Curtin Lee, Hawkins-Daarud Andrea, Hubbard Matthew E, Rahman Ruman, Smith Stuart J, Auer Dorothee, Tran Nhan L, Hu Leland S, Eschbacher Jennifer M, Smith Kris A, Stokes Ashley, Swanson Kristin R, Owen Markus R

Abstract excerpt

Glioblastomas (GBMs) are the most aggressive primary brain tumours and have no known cure. Each individual tumour comprises multiple sub-populations of genetically-distinct cells that may respond differently to targeted therapies and may contribute to disappointing clinical trial results. Image-localized biopsy techniques allow multiple biopsies to be taken during surgery and provide information that identifies...

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Identifiers

PMID: 33120534
DOI: 10.3934/mbe.2020267
PMCID: PMC8382158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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