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Article

G82S RAGE polymorphism influences amyloid-RAGE interactions relevant in Alzheimer's disease pathology.

PloS one - 1 Jan 2020

C Rani Cathrine, Lukose Bincy, Rani P

Abstract excerpt

Receptor for advanced glycation end products (RAGE) has been implicated in the pathophysiology of Alzheimers disease(AD) due to its ability to bind amyloid-beta (Aβ42) and mediate inflammatory response. G82S RAGE polymorphism is associated with AD but the molecular mechanism for this association is not understood. Our previous in silico study indicated a higher binding affinity for mutated G82S RAGE, which could...

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Share to Amyloid beta-Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33119615
DOI: 10.1371/journal.pone.0225487
PMCID: PMC7595441

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